Genome Mutiplex™ - anti-aging, cellular rejuvenation, longevity, optimal health & vitality.

Frequently Asked Questions

What is a Genome?

In biology the genome of an organism is its whole hereditary information and is encoded in the DNA. The cells of humans actually have two genomes - a chromosomal genome and a mitochondrial genome - which together make up the total genome.

Why is the HPAA so important?

"The HPAA is central to our entire endocrine system. Rather than consider the seven small glands that make up the endocrine system as separate entities, we should view them as one. Very often when one endocrine gland has a problem, other glands are also suffering. For example, with hypothyroidism we can often see reproductive hormones out of balance and/or insulin signaling being affected. What is even more important and often relative is that underneath all of this is an imbalance, or "lack of adaptability," centered in the HPAA. It is theorized that the central regulator - the hypothalamus - is responsible for the shifting of our body's metabolic homeostasis (allostatis).

The health of the HPAA Neuro-Endocrine system is the root of our entire body; it is truly the key to the strength of our "Life-Force".

(1)

"The disruption of the HPAA is often central to most health problems, syndromes, diseases, and even aging itself. For instance, if the HPAA is strong and vital, than a woman can often make an easy transition through menopause, but if the system is overworked and tired, than menopause can be very difficult and even other endocrine glands can suffer. I can truthfully say that almost all the people I see in my practice present symptoms that involve the HPAA.

The HPAA is the conduit for our emotions and psychological stress is primarily mediated through this axis. It has, like the whole neuro-endocrine system, far-reaching interaction with the other hormonal systems as well as with the rest of the auto-regulation systems." (1)

HPAA dysfunction has been shown to lead to some of the following conditions:

Dysregulation of catecholamines ("fight or flight" stress hormones)

Dysregulation of glucocorticoids (Adreno-corticoid stress hormones)

Dysregulation of cytokines (disrupted pro-inflammatory immune system responses)

Disruptions in cellular communication - cell receptors are desensitized

Atrophy of nerve cells in the amygdala and hippocampus of the brain

Bone mineral loss

High lipids (dyslipidemias)

Sarcopenia - loss of lean muscle mass (catabolic)

Abdominal or Truncal obesity

Increased risk of cardiovascular disease

Chronic fatigue

Mild depression and anxiety

Anorexia (cachexia)

Poor sleep patterns

Altered cognitive performance

Decreased sexual behavior (1)

Clearly, a balanced HPAA is critical to your good health and Genome Multiplex™ can play a major role in helping your body back to a state of homeostasis.

What is an Adaptogen?

The word adaptogen is used to refer to a natural herb product that increases the body's resistance to stresses such as trauma, anxiety and bodily fatigue. Very simply, adaptogens are nontoxic in normal doses, produce a non-specific defensive response to stress, and have a normalizing influence on the body. They normalize the Hypothalamic-Pituitary-Adrenal axis (HPA axis). As defined, adaptogens constitute a new class of natural, homeostatic metabolic regulators.

Adaptogenic herbs are unique from other substances in their ability to improve balance of endocrine hormones and the immune system, and they help the body to maintain optimal homeostasis. Adaptogens have a normalizing effect on the body and are capable of either "toning down" the activity of hyper-functioning systems or strengthening the activity of hypo-functioning systems.

"Although, generally speaking, adaptogens are not considered 'medicinal' in the normal sense of the word, they can and should be implemented into any and all holistic protocols whether treating disease, or promoting wellness. They should be used especially following illness, post surgery, and/or trauma to assist in recovery. Adaptogens combat the negative effects of stress, improve health and well being, and enhance athletic performance capacity. They increase the body's vitality and reserve, a key component to any comprehensive longevity program. They are revered because they enhance the 'Life-Force,' encourage natural harmony, enhance one's adaptability, and as a result, generate 'radiant health'." (1)

How does stress affect aging and illness?

You have heard the expression before: Stress is a killer! It is true, stress can and will kill you. We live in a fast-paced world. We constantly push our minds and bodies to the limit working long hours, fighting endless traffic on the roads, dealing with family-related issues, eating fast food on the run, etc. With the combined effects of a decrease in the quality of our food sources (depleted soils, GMO food production, processed and heat-treated food-stuffs), environmental pollution and the emotional stress induced by our fast-paced lives, our bodies are finding it harder and harder to successfully adapt and maintain metabolic equilibrium. As our bodies move out of equilibrium and become imbalanced, we become prone to illness and disease. Many conditions seen today are a result of the cumulative affects of stress and compromised adaptability.

Aging is characterized by a general decline in most physiologic functions, and in particular, by a decreased capacity to maintain homeostasis during episodes of stress. As the body loses its ability to maintain proper energetic balance, patterns of degradation of function can occur. The first documented record of such a pattern, "the maladaptive stress syndrome," was identified by Hans Selye in the 1950's, and has since been identified as the syndrome of "Adrenal Fatigue," and in more extreme cases, Adrenal Exhaustion, also known as "Nervous Breakdown."

"Genome Multiplex™ literally changed my life: improved sleep and elevated mood, more focus, an abundance of energy and most importantly, it reversed a severe prostate problem that I had."

- Bernard Brown, Dallas, TX.

These syndromes are characterized by the body's inability to adapt to the stresses of life. Many of the named diseases (including aging) have a root in the adrenal fatigue or maladaptive stress syndromes. Metabolic Syndrome, or Syndrome X, Diabetes, Chronic Fatigue Syndrome, Fibromyalgia, Hypothyroidism, Allergies, Asthma, etc. can all be traced to imbalances in the endocrine system, often brought on by the aforementioned stressors, and are often the early stages of further disease progression.

It is the endocrine system, and more specifically the HPAA, that is the target of Genome Multiplex™. The HPAA oversees the physical state of the body and directs the other endocrine organs. To do this effectively, it is dependent upon proper communication in the form of powerful and essential hormones. Genome Multiplex™ stimulates the body's natural production of hormones at levels that the human body requires to operate effectively. When the body's hormones are balanced, it will reach a state of homeostasis. Homeostasis, combined with the powerful adaptogenic effect of Genome Multiplex™, will enable the body to better cope with stress and this ultimately translates to optimal health, vitality and longevity.

How do free radicals damage our bodies?

Our bodies get their energy from the mitochondria in our cells. Mitochondria are the organelles that function as the cell "powerhouse", generating ATP, the universal form of energy used by all cells. It converts food nutrients such as glucose, to a fuel (ATP) that the cells of the body can use to perform all is tasks.

The problem is that when our mitochondria turn food into energy, they produce oxygen free radicals, molecules that cause dangerous inflammation in the mitochondria themselves as well as in the rest of the cell. There have been many theories of aging; one of the most significant is the free-radical theory proposed by Dr. Denham Harman.

A free radical is a molecule with an unpaired electron. Because they have a free electron, such molecules are highly reactive. The fact that they are highly reactive means that they have low chemical specificity; i.e. they can react with most molecules in its vicinity. This includes proteins, lipids, carbohydrates and DNA. It also means that in trying to gain stability by capturing the needed electron they do not survive in their original state for very long and quickly react with their surroundings. Hence, free radicals attack the nearest stable molecule, "stealing" its electron. When the "attacked" molecule loses its electron, it becomes a free radical itself, beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell. If a cell has no energy, it can no longer repair itself, resulting in cellular breakdown.

Free radicals can be killed off by antioxidants and Genome Multiplex™ can be of considerable help in this regard since it floods the body with antioxidants.

"Antioxidants are critical in anti-aging medicine because they act as natural anti-inflammatories, giving us protection against the inflammation initiated by free radicals that causes cellular damage. When this damage occurs internally to our vital organs, such as the brain, it results in problems such as Parkinson's disease, Alzheimer's, and dementia. It can also damage the lungs, resulting in decreased respiratory function, as well as the heart and the kidneys.

And it is not just our internal organs that suffer. Free-radical damage and inflammation is apparent in our appearance with each passing year. It manifests in very visible damage to skin, resulting in the thinning of the skin, deep lines, wrinkles, sagging, and loss of tone, texture, and radiance. Negative changes in our muscle mass, known as sarcopenia, along with the loss of critical bone mass (osteopenia and osteoporosis), also occur. Each of these changes, whether external or internal, is the initial result of damage on a molecular and cellular level." (2)

What is the difference between youth and age?

To a large degree, it is defined by hormonal balance and receptor site sensitivity. Hormones are chemical messengers; receptors to these hormones reside on the surface of our cells and are the recipients of these chemical messages (this is dealt with in depth below). Aging is in part due to a process of metabolic miscommunication in which the endocrinological messages from our master regulator glands, for one reason or another, do not reach their intended recipients: the organs and cells of our body.

When hormones are restored to their youthful levels, balance is reinstated (the body reaches homeostasis) and receptor site sensitivity is improved. And this is precisely what Genome Multiplex seeks to do!

How does a young body function?

Once a hormone is secreted, it travels from the endocrine gland that produced it through the bloodstream to the cells designed to receive its message. These cells are called target cells. Along the way to the target cells, special proteins bind to some of the hormones. These proteins act as carriers that control the amount of hormone that is available for the cells to use. The target cells have receptors that latch onto only specific hormones, and each hormone has its own receptor, so that each hormone will communicate only with specific target cells that have receptors for that hormone. When the hormone reaches its target cell, it locks onto the cell's specific receptors and these hormone-receptor combinations transmit chemical instructions to the inner workings of the cell. Genome Multiplex contains an ingredient that bonds to the receptors and thus improves communication between the cells.

When hormone levels reach a certain normal amount, the endocrine system helps the body to keep that level of hormone in the blood. For example, if the thyroid gland has secreted the right amount of thyroid hormones into the blood, the pituitary gland senses the normal levels of thyroid hormone in the bloodstream. Then the pituitary gland adjusts its release of thyrotropin, the hormone that stimulates the thyroid gland to produce thyroid hormones.

Another example of this process is parathyroid hormone. Parathyroid hormone increases the level of calcium in the blood. When the blood calcium level rises, the parathyroid glands sense the change and reduce their secretion of parathyroid hormone. This turnoff process is called a negative feedback system.

Yet another example is Somatotropin, the growth hormone. Once released by the pituitary gland, it travels in the circulation and is taken up principally by the liver where it stimulates the production of another hormone-like substance called Insulin-like Growth Factor -1 (IGF-1). IGF-1 is then released into the circulation where it attaches to cells in the body, and like insulin, triggers the cell to produce certain responses which, with IGF-1, are those of growth, regeneration and repair.

Levels of IGF-1 are monitored by the hypothalamus situated just above the pituitary gland. When maximal Somatotropin levels are attained for any individual, these levels trigger the release of Somatostatin, another brain chemical, which 'shuts the gate' in the pituitary gland, preventing further release of Somatotropin. This feedback loop prevents excessive levels of Somatotropin in the human body. Feedback loops are extremely efficient at preventing our hormone levels from exceeding our optimal levels.

In short, hormones orchestrate the incredible myriad of tasks carried out by the cells of our body. As such, they keep our metabolism in smooth running order.

What does Salutogenesis mean?

Salutogenesis is an alternative medicine concept that focuses on factors that support human health and well-being rather than on factors that cause disease. The term salutogenesis comes from the Latin salus = health and the Greek genesis = origin.

(1)	"Herbal and Nutritional Strategies for Harmonizing the Hypothalamus-Pituitary-Adrenal Axis (HPAA) and its Affects on the Endocrine System" - By Donald R. Yance Jr.CN, MH, AHG.
(2)	"Dr. Perricone's 7 Secrets to Beauty, Health, and Longevity: The Miracle of Cellular Rejuvenation" - by Dr. Nicholas Perricone, M.D.

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